¸¶ÀÌ ÆäÀÌÁö
ÀÇ»ç ȸ¿ø
¾à»çȸ¿ø
Ŭ·´
»çÀÌÆ®¸Ê
ÀÌ¿ë¾È³»
DoctorKorea
»ó´ãÁ¤º¸°Ë»ö
Áúº´Á¤º¸°Ë»ö
ÀÇÇÐÁ¤º¸°Ë»ö
°Ç°´º½º
ÀÇÇÐÅäÇÈ
|
¼¼°èÀÇÇдº½º
|
±¹³»ÀÇÇдº½º
¾à¹°°Ë»ö
ÀǾàÇ°°Ë»ö
|
ÀǾàÁ¤º¸µµ±¸
|
½Äº°Á¤º¸
|
º¹¾àÁöµµ
|
»óº´ÄÚµå
|
±Þ¿©½É»ç±âÁØ
|
»óÈ£ÀÛ¿ë
|
Áúº´Á¤º¸
ÀÚ°¡Áø´Ü
½ÅüºÎÀ§º° ÀÚ°¡Áø´Ü
|
½Ä»ýÈ°Å×½ºÆ®
|
ÇѹæüÁú Áø´Ü
Áúº´Á¤º¸
ÀϹÝÁúº´Á¤º¸
|
Ư¼öÁúȯÁ¤º¸
|
ÁÖÁ¦º° Áúº´Á¤º¸
|
½Åüº° Áúº´Á¤º¸
|
¿¬·Éº° Áúº´Á¤º¸
ÀÇÇÐÀÚ·á
Àü¹®°úº° ÀÇÇÐÀÚ·á
|
Àü¹®Çй®º° ÀÇÇÐÀÚ·á
°Ç°»ó´ã
°Ç°»ó´ã»ç·Ê
|
°Ç°»ó´ã½Ç
¿µ¾çÇÐ
ºñŸ¹Î
|
¿¬·Éº° ¿µ¾çÇÐ
|
Áúº´º° ½ÄÀÌ¿ä¹ý
|
°Ç°º¸Á¶½ÄÇ°
|
±â´É¼º½ÄÇ°
|
Ư¼ö¿µ¾ç½ÄÇ°
|
Çãºê ¡¤ ¾Æ·Î¸¶
|
µ¿½Ä¹°½ÄÇ°»ó½Ä
¾à¸®ÇÐ
±âº»¿ø¸®
|
ÀÚÀ²½Å°æ
|
½ÉÇ÷°ü-½ÅÀå
|
ÆòȲ±Ù
|
ÁßÃ߽Űæ
|
Ç÷¾×-¿°Áõ
|
³»ºÐºñ
|
ÈÇпä¹ý
|
µ¶¼ºÇÐ
|
ÁÖÁ¦º°
Ŭ·´
Ŭ·´Ã£±â
|
Ŭ·´¾È³»
|
³ªÀǺñ¹Ð°ø°£
|
³ªÀÇŬ·´
|
Á¤º¸±¤Àå
ºÎ°¡¼ºñ½º
°øÁö»çÇ×
½ÉºÎÁ¤¸Æ¾àÁ¦
ºÐ·ù
¼±ÅÃ
°íÇ÷¾ÐÄ¡·áÁ¦ [49]
½ÉºÎÀüÄ¡·áÁ¦, ½É¹è´çü [15]
½ÉºÎÁ¤¸Æ¾àÁ¦ [30]
ÀÌ´¢Á¦ [10]
Ç÷°üÈ®ÀåÁ¦-Çù½ÉÁõÄ¡·áÁ¦ [27]
Á¦¸ñ
½ÉÇ÷°ü »ý¸®(Cardiovascular physiology)
ÀÛ¼ºÀÚ
´ÚÅÍÄÚ¸®¾Æ
Á¶È¸¼ö
7308
½ÉÇ÷°ü »ý¸®(Cardiovascular physiology)
1) Ç÷¿ªÇÐÀû ¿ä¼Ò(Hemodynamic factors)
¡¡½É¹ÚÃâ·®Àº ½É¹Ú¼ö¿Í ÀÏȸ ¹ÚÃâ·®¿¡ ÀÇÇØ °áÁ¤µÈ´Ù. ÀÏȸ ¹ÚÃâ·®Àº ÀüºÎÇÏ, ÈĺÎÇÏ, ½É±Ù ¼öÃà·Â µîÀÇ ¿ä¼Ò¿¡ ÀÇÇØ °áÁ¤µÇ¸ç, ÀÌ°ÍÀ» °ø½ÄÀ¸·Î ³ªÅ¸³»¸é ´ÙÀ½°ú °°´Ù.
¡¡¡¡¡¡½É¹ÚÃâ·® = ½É¹Ú¼ö X ÀÏȸ ¹ÚÃâ·®¡¡.......................................[1]
¡¡¡¡¡¡(cardiac output = heart rate X stroke volume)
¡¡Ç÷¾ÐÀº ½É¹ÚÃâ·®°ú Àü½Å Ç÷°ü ÀúÇ׿¡ ÀÇÇØ °áÁ¤µÈ´Ù. Ç÷°üÀۿ뼺 ¾à¹°Àº ½É¹Ú¼ö, ½É±ÙÀÇ ¼öÃà·Â, ¹æ½Ç Àüµµ¼º ¶Ç´Â Àü½Å Ç÷°ü ÀúÇ×À» º¯È½ÃÅ°¹Ç·Î½á ¾à¸®ÇÐÀû È¿°ú¸¦ ³ªÅ¸³»¸ç, ÀÌ¿¡ °ü·ÃµÈ °ø½ÄÀº ´ÙÀ½°ú °°´Ù.
¡¡¡¡¡¡Ç÷¾Ð = ½É¹ÚÃâ·® X Àü½Å Ç÷°ü ÀúÇס¡.......................................[2]
¡¡¡¡¡¡(blood pressure = cardiac output X systemic vascular resistance)
¡¡ÀÌ·¯ÇÑ Ç÷°üÀۿ뼺 ¾à¹°ÀÇ Á÷Á¢ÀûÀÎ ÀÛ¿ëÀº ½É¹Ú¼ö, ½É±Ù ¼öÃà·Â, ¹æ½Ç Àüµµ¼º ¶Ç´Â Àü½Å Ç÷°ü ÀúÇ×À» º¯È½ÃÅ°¹Ç·Î½á ½É¹ÚÃâ·®, ÀÏȸ ¹ÚÃâ·®, Ç÷¾Ð µîÀÇ º¯È¸¦ ÀÌÂ÷ÀûÀ¸·Î ÃÊ·¡ÇÒ ¼ö ÀÖ´Ù.
2) ÀÚÀ² ½Å°æ°è(Autonomic nervous system)
¡¡ÀÚÀ² ½Å°æ°è´Â ±³°¨ ½Å°æ°è¿Í ºÎ±³°¨ ½Å°æ°è·Î ±¸¼ºµÇ¾î ÀÖ´Ù. ±³°¨ ½Å°æ°è´Â ÁÖ·Î Èä¿äÃß(thoracolumbar)ºÎÀ§¸¦ ÁÖÇàÇϸç Á¢ÇÕ ºÎÀ§¿¡¼ ½Å°æ Àü´Þ ¹°Áú·Î ³ë¸£¿¡Çdz×ÇÁ¸°(norepinephrine)ÀÌ ÀÛ¿ëÇÏ°í, ºÎ±³°¨ ½Å°æ°è´Â ÁÖ·Î °æÃߺÎ(cervical)¿Í õ°ñ(sacral) ºÎÀ§¸¦ ÁÖÇàÇÏ¸ç ½Å°æÀý°ú Á¢ÇÕ ºÎÀ§¿¡¼ ½Å°æ Àü´Þ ¹°Áú·Î ¾Æ¼¼Æ¿Äݸ°(acetylcholine)ÀÌ ÀÛ¿ëÇÑ´Ù.
¡¡½Å°æ Àü´Þ ¹°Áú°ú Ç÷°üÀۿ뼺 ¾à¹°µéÀº ¿øÇÏ´Â »ý¸®ÇÐÀû ¹ÝÀÀÀ» ¾ò±â À§ÇØ ¼·Î ´Ù¸¥ ¼ö¿ëü¿Í »óÈ£ÀÛ¿ëÀ» ÇÑ´Ù. ÀÌ¿Í°°Àº ÀÛ¿ëÀº ÀÌ¹Ì ÀÎÁ¤µÈ ÀÌ·ÐÀ¸·Î, ÀÌ·¯ÇÑ ¼ö¿ëüµéÀÇ Á¸Àç´Â ºñ±³Àû ÃÖ±Ù¿¡ ¹ß°ßµÈ °ÍµéÀÌ´Ù. ÃÖ±Ù¿¡¾ß ¼ö¿ëüµéÀº È£¸£¸óÀ̳ª ¾à¹°°ú °áÇÕÇÏ´Â ´Ü¹éÁúÀ̶ó´Â °ÍÀÌ Áõ¸íµÇ¾ú´Ù. ¶ÇÇÑ ¼ö¿ëüÀÇ Á¾·ùµéÀº ¼öÃà·Â°ú ¼±ÅÃÀûÀÎ ±æÇ×Á¦¿ÍÀÇ °áÇÕ, ÀÌÂ÷Àü·É°æ·Î(second messenger pathway), °¢°¢ ´Ù¸¥ À¯ÀüÀÚ ±¸Á¶ µî¿¡ µû¶ó °áÁ¤µÈ´Ù.
3) ¼ö¿ëü »ý¸®ÇÐ
¡¡¼ö¿ëüµéÀº Ư¡ÀûÀ¸·Î ¼¼Æ÷¸·°ú ¼¼Æ÷Áú µÎ °÷¿¡ À§Ä¡ÇÑ´Ù. ´ë´Ù¼öÀÇ ¾àµé°ú ³»Àμº È£¸£¸óµéÀº Ä£¼ö¼ºÀ̸ç Áö¹æ¼º ¼¼Æ÷¸·Àº Àß Åë°úÇÏÁö ¸øÇÑ´Ù. ±×·¯¹Ç·Î ÀÓ»óÀÇ¿¡°Ô Áß¿äÇÑ ´ëºÎºÐÀÇ ¼ö¿ëü ±â°üµéÀº ¼¼Æ÷¸·¿¡ ºÎÂøµÈ È°¼ºÈµÇ±â ½¬¿î ´Ü¹éÁúµéÀÌ´Ù. º¸ÅëÀÇ ¸· ¼ö¿ëü ½ÅÈ£µµÀÔ(transmembrane receptor-signal transdution)Àº È°¼ºÈµÈ ¼ö¿ëü¿Í ¸Å°³¹°ÀÎ guanine nucleotide protein(G protein)°úÀÇ »óÈ£ÀÛ¿ëÀ¸·Î ³ªÅ¸³´Ù. ¿¡³ÊÁö¸¦ Á¦°øÇϱâ À§ÇØ guanine triphosphate(GTP)°¡ guanine diphosphate(GDP)·Î °¡¼öºÐÇØµÈ ÈÄ, ÀÌ »óÈ£ÀÛ¿ëÀº ÀÌÂ÷ Àü·É(second messenger)À» È°¼ºÈ ½ÃŲ´Ù(±×¸² 2). ±× ÈÄ ¼¼Æ÷³»ÀÇ ÈÇÐÀûÀÎ ¿¬¼Ó ¹ÝÀÀÀÌ °á±¹ ¿øÇÏ´Â ÀÓ»óÀû °á°ú¸¦ À¯µµÇÑ´Ù. º£Å¸ ¾Æµå·¹³¯¸°¼º ¼ö¿ëüÀÇ °æ¿ì, ÃËÁøÁ¦°¡ ÀÚ±ØÇÑ G- proteinÀÌ adenyl cyclase¸¦ È°¼ºÈ½ÃÄÑ °á°úÀûÀ¸·Î ¼¼Æ÷³» cyclic adenosine monophosphate(c-AMP)°¡ Áõ°¡ÇÑ´Ù3). °íÀüÀûÀÎ ¾Æµå·¹³¯¸°¼º ¼ö¿ëü(¾ËÆÄ 1, ¾ËÆÄ 2, º£Å¸ 1, º£Å¸ 2)´Â ½ÉÇ÷°ü°èÀÇ Ç×»ó¼º À¯Áö¸¦ À§ÇØ ¼ö¿ëü¿Í °áÇÕÇÏ´Â °¡Àå Áß¿äÇÑ G-proteinÀÌ´Ù. µµÆĹΠ¼ö¿ëü¸¦ Æ÷ÇÔÇÑ ¾Æµå·¹³¯¸°¼º ¼ö¿ëüÀÇ Æ¯¼ºµéÀº Ç¥¿Í ´ÙÀ½ ¹®Àå¿¡ Àß ³ªÅ¸³ª ÀÖ´Ù.
¸·¼ö¿ëü ½ÅÈ£µµÀÔ.
Hydrophilic endogenous hormone (H)À̳ª exogenous drug(D)ÀÌ ¸·¼ö¿ëü[transmembrane receptor(R)]ÀÇ ¼¼Æ÷¿Ü ¸é°ú °áÇÕÇÏ°í ÀÖ´Ù. ±× ´ÙÀ½ activated receptor´Â cytoplasmic intermediary guanine nucleotide protein(G)°ú »óÈ£ÀÛ¿ëÀ» ÇÑ´Ù. Guanine triphosphate(GTP)°¡ guanine diphosphate(GDP)·ÎÀÇ hydrolysis´Â effector molecule(E)°ú »óÈ£ÀÛ¿ëÇÏ´Â G protein¿¡ ÇÊ¿äÇÑ ¿¡³ÊÁö¸¦ ¿ä±¸ÇÑ´Ù. Effector moleculeÀÇ È°¼ºÀ̳ª ¾ïÁ¦´Â ¼¼Æ÷³»·ÎÀÇ ÈÇйÝÀÀÀ» ÀÏÀ¸Å²´Ù2).
Ä«Å×Äݾƹο¡ ÀÇÇÑ ¼ö¿ëü ÀÚ±ØÀÇ È¿°ú
Adrenergic receptor
Site
Action
Alpha-1
Postsynaptic receptors that regulate smooth muscle arterioles(systemic and pulmonary circulation) Vasoconstriction(increased impedance)
Iris Dilatation
Heart Increased contractility
Alpha-2
Presynaptic receptors that inhibit the release of norepinephrine of smooth muscle when stimulated Vasodilation
Beta-1
Heart Increased atrial and ventricular contraction
Sinoatrial node Increased heart rate
Atrioventricular conduction Increased conduction velocity or rate of conduction
Kidney Renin release
Beta-2
Smooth muscle arterioles(systemic and pulmonary) Vasodilatation(decreased impedance)
Bronchi Bronchodilatation
Heart Increased rate and contractility
Dopamine-1
Vascular smooth muscle
Renal and mesentery Vasodilation
Dopamine-2
Presynaptic adrenergic nerve endings Inhibits norepinephrine release
¡¡½ÉÇ÷°ü°è¸¦ ºü¸£°Ô Á¶ÀýÇÏ´Â ´ëºÎºÐÀÇ Ç÷°üÀۿ뼺 ¾à¹°µéÀº ¾Æµå·¹³¯¸°¼º ¼ö¿ëü¸¦ ÅëÇØ ±×µéÀÇ È¿°ú¸¦ ³ªÅ¸³½´Ù. ±×·¯¹Ç·Î, ¾Æµå·¹³¯¸°¼º ¼ö¿ëü¸¦ ÀÌÇØÇÏ´Â °ÍÀÌ Ç÷°üÀÛ¿ë ¾à¹°ÀÇ ¾àÈ¿¸¦ ÀÌÇØÇϱâ À§Çؼ ÇÊ¿äÇÏ´Ù. ÃÖ±ÙÀÇ ¿¬±¸ °á°ú ¾ËÆÄ¿Í º£Å¸ ¼ö¿ëüÀÇ ¸¹Àº ¾ÆÀ¯Çü(subtype)ÀÌ ¹àÇôÁ³´Ù(±×¸² 3). ÀÌ·¯ÇÑ ¸¹Àº ¾ÆÀ¯Çü(subtype)µéÀº ´ëºÎºÐ ºó¹øÇÏ°Ô ÀÌ¿ëµÇ´Â Ç÷°üÀۿ뼺 ¾à¹°µéÀÌ subgroup¿¡ Ư¡ÀûÀÌÁö ¾Ê±â ¶§¹®¿¡ ÀÏÂ÷ÀûÀ¸·Î Çй®ÀûÀÎ °ü½ÉÀÇ ´ë»óÀÌ µÇ¾ú´Ù. ±×·¯³ª ÀÌµé ¼ö¿ëüÀÇ ºÐ·ù, ü³»ÀÇ À§Ä¡¿Í ¼ö¿ëüÀÇ ÃËÁøÀ̳ª ±æÇ×ÀÇ È¿°úµéÀº ¾àÈ¿»Ó¸¸ ¾Æ´Ï¶ó »õ·Ó°í ´õ¿í ƯÀÌÀûÀ¸·Î ÀÛ¿ëÇÏ´Â ¾à¹°À» »ý»êÇϴµ¥ ÁöÇ¥¸¦ Á¦°øÇÏ¿´´Ù. ¼ö¿ëü ¾à¸®ÇÐÀ» ÀÌÇØÇÔÀ¸·Î½á ÀÓ»óÀǵéÀº ¿øÇÏ´Â Ç÷¿ªÇÐÀû È¿°ú¸¦ ¾ò±â À§ÇØ ±³°¨ ½Å°æ°è¸¦ Á¶ÀýÇÏ´Â µ¥¿¡ ÀûÀýÇÑ ¾à¹°µéÀ» ¼±ÅÃÇÒ ¼ö ÀÖ´Ù.
¾ÆÀ̵ðÀúÀå
ȸ¿ø°¡ÀÔ
¾ÆÀ̵ð/ºñ¹Ð¹øȣã±â
°Ç°»ó´ã»ç·Ê
more
Áúº´Á¤º¸
more
ÀÇÇÐÀÚ·á
more
˂ȍ
ȸ¿ø ¾È³»
¾à»ç
ȸ¿ø ¾È³»
Family Site
Family Site1
Family Site2
Family Site3
Copyright Doctorkorea Inc. All rights reserved
¼¿ï½Ã °³²±¸ Å×Çì¶õ·Î52±æ 21 (¿ª»ïµ¿,º¥Ã³ºôµù4Ãþ) ¿î¿µÀÚ À¯ÀçÈ
T
:
010-9002-5788
E
:
alla@doctorkorea.com
°³ÀÎÁ¤º¸ º¸È£Á¤Ã¥
À̸ÞÀÏÁ¤º¸ ¹«´Ü¼öÁý°ÅºÎ