¾à¸®ÇÐ: ÁßÃ߽Űæ°è, ÁøÅëÁ¦
ÀÛ¼ºÀÚ ´ÚÅÍÄÚ¸®¾Æ Á¶È¸¼ö 7831ÁøÅëÁ¦(analgesics)
1. ¸¶¾à¼ºÁøÅëÁ¦(opioid analgesics)
opioids ¼ö¿ëü
ÁßÃ߽Űæ°è(ô¼ö, ½Ã»ó, ³ú°£, ´ë³úº¯¿¬°è, ½Ã»ó)¿Í À§Àå°üÀÇ ¼¼Æ÷¸·¿¡ Á¸ÀçÇÏ´Â ¼ö¿ëü·Î¼ ÅëÁõ ÀÚ±Ø Àü´Þ¹°ÁúÀÎ substance pÀÇ À¯¸®¸¦ ¾ïÁ¦ÇÏ¿© ÁøÅëÀÛ¿ëÀ» ÇÑ´Ù.
¼ö¿ëü |
ÀÛ¿ë |
¹Â(μ) ¼ö¿ëü |
¸ôÇÉ¾ç »óºÎ ô¼ö ÁøÅë, Äè°¨, È£Èí¾ïÁ¦, ½Åü±â´ÉÀúÇÏ |
Ä«ÆÄ(κ) ¼ö¿ëü |
ÆæŸÁ¶½Å¾ç ô¼öÁøÅë, ÁøÁ¤, Ãൿ |
µ¨Å¸(δ) ¼ö¿ëü |
ºÒÄè, ȯ°¢, ±æÇ×Á¦¿¡ ÀÇÇÑ È£Èí ÀÚ±Ø ¹× Ç÷°ü¿îµ¿¼º ÀÚ±Ø |
1) ¸¶¾à¼º ÁøÅëÁ¦ (opioid agonist)
• ÀÛ¿ë±âÀü : μ-¼ö¿ëü¿¡ ÀÛ¿ëÇÏ¿© substance pÀ¯¸®¸¦ °¨¼Ò½ÃÄÑ Åë°¢ Àü´ÞÀ» ¾ïÁ¦
• Á¾·ù : morphine, codeine, meperidine, hydrocodone, fentanyl, sufentanil, heroin
2) ¸¶¾à±æÇ×¼º ÁøÅëÁ¦ (opioid agonist-antagonists)
• ÀÛ¿ë±âÀü : κ-È¿´ÉÀÛ¿ë(ÁøÅë,ÁøÁ¤) + μ-±æÇ×ÀÛ¿ë
• Á¾·ù : nalbuphine, pentazocine ,pentazocine, buprenorphine
• ÀÛ¿ë±âÀü : opioid ¼ö¿ëü ±æÇ×ÀÛ¿ë
• Á¾·ù : naloxone, naltrexone
• ÀÀ¿ë : ¸¶¾àÀÇ ±Þ¼ºÁßµ¶½Ã »ç¿ë
2. ÁßÃß¼ºÁøÅëÁ¦
• ÀÛ¿ë±âÀü : μ-opioid ¼ö¿ëü¿¡ ´ëÇÑ ¾àÇÑ È¿ÇöÀÛ¿ë
norepinephrine°ú serotoninÀÇ reuptake¸¦ ¾ïÁ¦ÇÏ´Â ÀÛ¿ë
• Á¾·ù : tramadol.
3. ÇØ¿ÁøÅëÁ¦ (nsaids, non-steroidal anti-inflammatory drug)
• ÀÛ¿ë±âÀü : cyclooxygenase ¾ïÁ¦¸¦ ÅëÇØ prostaglandin ÇÕ¼º¾ïÁ¦
ÇØ¿, ÁøÅë, Ç׿°Áõ È¿°ú
• cox-1(Á¤»óÀû »ý¸®±â´É À¯Áö) :
À§ÀåÁ¡¸·º¸È£,
½ÅÀåÇ÷·ùÁ¶Àý,
Á¤»óÀû Ç÷¼ÒÆÇ ±â´ÉÀ¯Áö
• cox-2(¿°Áõ¹ÝÀÀ Áõ°¡) :
¿°Áõ
¹ß¿
ÅëÁõ
ºÎÁ¾
1) ºñ¼±ÅÃÀû cox-2 ¾ïÁ¦Á¦
• ºÎÀÛ¿ë : À§Àå°ü »óÇǼջó, ¿°Áõ, ÃâÇ÷, ±Ë¾ç, ±«»ç ¹× ½ÅÀå¼Õ»ó
¨ç salicylates À¯µµÃ¼
a. acetylsalicylic acid (¾Æ½ºÇǸ°)
• ÀÀ¿ë : ÁøÅëÁ¦, ½ÉÇ÷°ü°èÁúȯ¿¹¹æ(Ç÷Àü»ý¼º¹æÁö)
b. diflunisal : ÁøÅë, Ç׿°ÁõÀÛ¿ëÀº ¾Æ½ºÇǸ°º¸´Ù °Çϳª ÇØ¿ÀÛ¿ëÀÌ ¾àÇÔ
¨è para-aminophenol À¯µµÃ¼
a. acetaminophen (ŸÀÌ·¹³î)
• ÀÛ¿ë : ÇØ¿,ÁøÅëÀÛ¿ëÀº ¾Æ½ºÇǸ°°ú À¯»ç, Ç׿°ÁõÀÛ¿ëÀº ¾àÇÔ.ÁßÃßÀÇ cox¾ïÁ¦
• ºÎÀÛ¿ë : °£µ¶¼º (¼Ò¾Æ¿¡°Ô ŸÀÌ·¹³îerÁ¤ ºÐÇÒ,ºÐ¼â Åõ¿©½Ã Àúü¿ÂÁõ À§Çè)
¨é propionic acid À¯µµÃ¼ : ibuprofen, ketoprofen, naproxen
¨ê acetic acid À¯µµÃ¼: indomethacin, sulindac, etodolac, mefenamic acid
¨ë oxicam À¯µµÃ¼ : piroxicam, meloxicam
¨ì alkanone : nabumetone
2) ¼±ÅÃÀû cox-2 ¾ïÁ¦Á¦
¿°Áõ¹ÝÀÀ¿¡ °ü°èÇÏ´Â cox-2¸¸ ¼±ÅÃÀûÀ¸·Î ¾ïÁ¦ÇÏ¿© À§Àå°üºÎÀÛ¿ë °¨¼Ò
• Á¾·ù : celecoxib, rofecoxib, nimesulide
• ºÎÀÛ¿ë : Àå±âº¹¿ë½Ã ½ÉÇ÷°üÁúȯ À§Çè Áõ°¡