¾ÆÆí°èÁøÅëÁ¦-±æÇ×Á¦

ºÐ·ù  

¾à¸®ÇÐ: ÁßÃ߽Űæ°è, ÁøÅëÁ¦

ÀÛ¼ºÀÚ ´ÚÅÍÄÚ¸®¾Æ Á¶È¸¼ö 7831

ÁøÅëÁ¦(analgesics) 

 

 

1. ¸¶¾à¼ºÁøÅëÁ¦(opioid analgesics)

 

opioids ¼ö¿ëü

ÁßÃ߽Űæ°è(ô¼ö, ½Ã»ó, ³ú°£, ´ë³úº¯¿¬°è, ½Ã»ó)¿Í À§Àå°üÀÇ ¼¼Æ÷¸·¿¡ Á¸ÀçÇÏ´Â ¼ö¿ëü·Î¼­ ÅëÁõ ÀÚ±Ø Àü´Þ¹°ÁúÀÎ substance pÀÇ À¯¸®¸¦ ¾ïÁ¦ÇÏ¿© ÁøÅëÀÛ¿ëÀ» ÇÑ´Ù.

 

¼ö¿ëü

ÀÛ¿ë

¹Â(μ) ¼ö¿ëü

¸ôÇÉ¾ç »óºÎ ô¼ö ÁøÅë, Äè°¨, È£Èí¾ïÁ¦, ½Åü±â´ÉÀúÇÏ

Ä«ÆÄ(κ) ¼ö¿ëü

ÆæŸÁ¶½Å¾ç ô¼öÁøÅë, ÁøÁ¤, Ãൿ

µ¨Å¸(δ) ¼ö¿ëü

ºÒÄè, ȯ°¢, ±æÇ×Á¦¿¡ ÀÇÇÑ È£Èí ÀÚ±Ø ¹× Ç÷°ü¿îµ¿¼º ÀÚ±Ø

¡Ø ³»Àμº morphine¾ç ¹°Áú : endorphins, enkephalins, dynorphins

 

 

1) ¸¶¾à¼º ÁøÅëÁ¦ (opioid agonist)

• ÀÛ¿ë±âÀü : μ-¼ö¿ëü¿¡ ÀÛ¿ëÇÏ¿© substance pÀ¯¸®¸¦ °¨¼Ò½ÃÄÑ Åë°¢ Àü´ÞÀ» ¾ïÁ¦

• Á¾·ù : morphine, codeine, meperidine, hydrocodone, fentanyl, sufentanil, heroin

 

2) ¸¶¾à±æÇ×¼º ÁøÅëÁ¦ (opioid agonist-antagonists)

• ÀÛ¿ë±âÀü : κ-È¿´ÉÀÛ¿ë(ÁøÅë,ÁøÁ¤) + μ-±æÇ×ÀÛ¿ë

• Á¾·ù : nalbuphine, pentazocine ,pentazocine, buprenorphine

• ÀÛ¿ë±âÀü : opioid ¼ö¿ëü ±æÇ×ÀÛ¿ë

• Á¾·ù : naloxone, naltrexone

• ÀÀ¿ë : ¸¶¾àÀÇ ±Þ¼ºÁßµ¶½Ã »ç¿ë

 

 

 

2. ÁßÃß¼ºÁøÅëÁ¦

• ÀÛ¿ë±âÀü : μ-opioid ¼ö¿ëü¿¡ ´ëÇÑ ¾àÇÑ È¿ÇöÀÛ¿ë

                   norepinephrine°ú serotoninÀÇ reuptake¸¦ ¾ïÁ¦ÇÏ´Â ÀÛ¿ë

• Á¾·ù : tramadol.

 

 

 

 

3. ÇØ¿­ÁøÅëÁ¦ (nsaids, non-steroidal anti-inflammatory drug)

• ÀÛ¿ë±âÀü : cyclooxygenase ¾ïÁ¦¸¦ ÅëÇØ prostaglandin ÇÕ¼º¾ïÁ¦

                   ÇØ¿­, ÁøÅë, Ç׿°Áõ È¿°ú

 

 

• cox-1(Á¤»óÀû »ý¸®±â´É À¯Áö) :

À§ÀåÁ¡¸·º¸È£,

½ÅÀåÇ÷·ùÁ¶Àý,

Á¤»óÀû Ç÷¼ÒÆÇ ±â´ÉÀ¯Áö

 

• cox-2(¿°Áõ¹ÝÀÀ Áõ°¡) :

¿°Áõ

¹ß¿­

ÅëÁõ

ºÎÁ¾

 

1) ºñ¼±ÅÃÀû cox-2 ¾ïÁ¦Á¦

• ºÎÀÛ¿ë : À§Àå°ü »óÇǼջó, ¿°Áõ, ÃâÇ÷, ±Ë¾ç, ±«»ç ¹× ½ÅÀå¼Õ»ó

 

¨ç salicylates À¯µµÃ¼

a. acetylsalicylic acid (¾Æ½ºÇǸ°)

• ÀÀ¿ë : ÁøÅëÁ¦, ½ÉÇ÷°ü°èÁúȯ¿¹¹æ(Ç÷Àü»ý¼º¹æÁö)

b. diflunisal : ÁøÅë, Ç׿°ÁõÀÛ¿ëÀº ¾Æ½ºÇǸ°º¸´Ù °­Çϳª ÇØ¿­ÀÛ¿ëÀÌ ¾àÇÔ

 

¨è para-aminophenol À¯µµÃ¼

a. acetaminophen (ŸÀÌ·¹³î)

• ÀÛ¿ë : ÇØ¿­,ÁøÅëÀÛ¿ëÀº ¾Æ½ºÇǸ°°ú À¯»ç, Ç׿°ÁõÀÛ¿ëÀº ¾àÇÔ.ÁßÃßÀÇ cox¾ïÁ¦

• ºÎÀÛ¿ë : °£µ¶¼º (¼Ò¾Æ¿¡°Ô ŸÀÌ·¹³îerÁ¤ ºÐÇÒ,ºÐ¼â Åõ¿©½Ã Àúü¿ÂÁõ À§Çè)

 

¨é propionic acid À¯µµÃ¼ : ibuprofen, ketoprofen, naproxen

¨ê acetic acid À¯µµÃ¼: indomethacin, sulindac, etodolac, mefenamic acid

¨ë oxicam À¯µµÃ¼ : piroxicam, meloxicam

¨ì alkanone : nabumetone

 

 

2) ¼±ÅÃÀû cox-2 ¾ïÁ¦Á¦

¿°Áõ¹ÝÀÀ¿¡ °ü°èÇÏ´Â cox-2¸¸ ¼±ÅÃÀûÀ¸·Î ¾ïÁ¦ÇÏ¿© À§Àå°üºÎÀÛ¿ë °¨¼Ò

• Á¾·ù : celecoxib, rofecoxib, nimesulide

• ºÎÀÛ¿ë : Àå±âº¹¿ë½Ã ½ÉÇ÷°üÁúȯ À§Çè Áõ°¡

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